[Criteria] [Data capture] [Data items] [Work-plan]
Eligibility criteria
Data will be collected on women between the age of 40 and 49 offered annual mammography (recruited at ages 40-<45 to ensure that each subject contributes five years of observation below age 50), who fulfil at least one of the criteria below.
Inclusion criteria
- 1 first degree female - breast cancer diagnosed at age 40 or less.
- 1 first degree female - bilateral breast cancer first cancer diagnosed at age 50 or less.
- 2 first or 1 first and 1 second degree female – both with breast cancer at age 60 or less (same side of family) (please do not average the ages).
- 1 first or second degree female - breast and ovarian cancer first cancer diagnosed at age 60 or less.
- 3 first or second degree female - breast or ovarian cancer at any age (same side of family) (please do not average the ages).
- 1 first degree male - breast cancer at any age.
- Paternal history of a minimum of 2 second degree relatives (NB. father's first degree relatives) with breast cancer diagnosed age 50 or less or breast diagnosed age 50 or less and an ovarian cancer (any age), or paternal uncle/grandfather with breast cancer diagnosed age 50 years or less (please do not average the ages).
A first degree female relative is mother/sister/daughter.
A second degree female relative is granddaughter/grandmother/aunt/niece.
A paternal relative is on father's side.
Exclusion criteria
- Inability to give written informed consent.
- Pregnant women.
- Women below the age of 40.
- Women with proven breast cancer or ductal carcinoma in situ.
- Women who have had bilateral prophylactic mastectomy.
- Women in whom a BRCA1 or BRCA2 mutation is present in the family, but who have been tested negative for the mutation.*
* This exclusion criteria has been added since the original protocol was written.